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Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): an update three years after its discovery.
Abstract Discovered in 2017, swine enteric alphacoronavirus (SeACoV), also known as swine acute diarrhea syndrome coronavirus (SADS-CoV) or porcine enteric alphacoronavirus (PEAV), is the fifth porcine CoV identified in diarrheal piglets. The presumed name "SADS-CoV" may not be appropriate since current studies have not provided strong evidence for high pathogenicity of the virus. SeACoV was the most recently recognized CoV of potential bat origin prior to the novel human severe acute respiratory syndrome CoV 2 (SARS-CoV-2), associated with the pandemic CoV disease 2019 (COVID-19). Although SeACoV is recognized as...
Source: Virus Research - May 15, 2020 Category: Virology Authors: Yang YL, Yu JQ, Huang YW Tags: Virus Res Source Type: research

Swine coronaviruses (SCoVs) and their emerging threats to swine population, inter-species transmission, exploring the susceptibility of pigs for SARS-CoV-2 and zoonotic concerns
Vet Q. 2022 May 18:1-39. doi: 10.1080/01652176.2022.2079756. Online ahead of print.ABSTRACTSwine coronaviruses (SCoVs) are one of the most devastating pathogens affecting the livelihoods of farmers and swine industry across the world. These include transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine respiratory coronavirus (PRCV), porcine hemagglutinating encephalomyelitis virus (PHEV), swine acute diarrhea syndrome coronavirus (SADS-CoV), and porcine delta coronavirus (PDCoV). Coronaviruses infect a wide variety of animal species and humans because these are having single stranded-R...
Source: Veterinary Quarterly - May 18, 2022 Category: Veterinary Research Authors: Jigarji C Thakor Murali Dinesh Rajendran Manikandan Suresh Bindu Monalisa Sahoo Diptimayee Sahoo Manish Dhawan Megha Katare Pandey Ruchi Tiwari Talha Bin Emran Kuldeep Dhama Wanpen Chaicumpa Source Type: research

Viruses, Vol. 14, Pages 1358: Development and Validation of Indirect Enzyme-Linked Immunosorbent Assays for Detecting Antibodies to SARS-CoV-2 in Cattle, Swine, and Chicken
ari Kapur Vandegrift Maranas Nair Kuchipudi Multiple domestic and wild animal species are susceptible to SARS-CoV-2 infection. Cattle and swine are susceptible to experimental SARS-CoV-2 infection. The unchecked transmission of SARS-CoV-2 in animal hosts could lead to virus adaptation and the emergence of novel variants. In addition, the spillover and subsequent adaptation of SARS-CoV-2 in livestock could significantly impact food security as well as animal and public health. Therefore, it is essential to monitor livestock species for SARS-CoV-2 spillover. We developed and optimized species-specific indi...
Source: Viruses - June 22, 2022 Category: Virology Authors: Gontu Marlin Ramasamy Neerukonda Anil Morgan Quraishi Chen Boorla Nissly Jakka Chothe Ravichandran Kodali Amirthalingam LaBella Kelly Natesan Minns Rossi Werner Hovingh Lindner Tewari Kapur Vandegrift Maranas Nair Kuchipudi Tags: Article Source Type: research

Viruses, Vol. 13, Pages 1506: Intravenous, Intratracheal, and Intranasal Inoculation of Swine with SARS-CoV-2
Diego G. Diel Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the susceptibility of animals and their potential to act as reservoirs or intermediate hosts for the virus has been of significant interest. Pigs are susceptible to multiple coronaviruses and have been used as an animal model for other human infectious diseases. Research groups have experimentally challenged swine with human SARS-CoV-2 isolates with results suggesting limited to no viral replication. For this study, a SARS-CoV-2 isolate obtained from a tiger which is identical to human SARS-CoV-2 isolates detected in New ...
Source: Viruses - July 30, 2021 Category: Virology Authors: Alexandra Buckley Shollie Falkenberg Mathias Martins Melissa Laverack Mitchell V. Palmer Kelly Lager Diego G. Diel Tags: Article Source Type: research

A useful tool for the safe diagnosis and control of the two main pandemics of the XXI century: COVID-19 and African Swine Fever disease
by Sandra Barroso-Ar évalo, Marta Díaz-Frutos, Aleksandra Kosowska, Marta Pérez-Sancho, Lucas Domínguez, José Manuel Sánchez-Vizcaíno The COVID-19 pandemic and the disease triggered by the African Swine Fever virus are currently two of the main problems regarding public and animal health, respectively. Although vaccination seems to be the ideal tool for controlling these diseases, it has several limitations. Therefore, early det ection of the pathogen is critical in order to apply preventive and control measures. Real-time PCR is the main technique used for the detection of both viruses, which requires previous pro...
Source: PLoS One - March 6, 2023 Category: Biomedical Science Authors: Sandra Barroso-Ar évalo Source Type: research

Pharmacokinetics and safety of XAV-19, a swine glyco-humanized polyclonal anti-SARS-CoV-2 antibody, for COVID-19-related moderate pneumonia: a randomized, double-blind, placebo-controlled, phase IIa study
Conclusions: Single intravenous dose of 2mg/kg of XAV-19 demonstrated high serum concentrations, predictive of potent durable neutralizing activity with good tolerability. Trial registration: ClinicalTrials.gov Identifier: NCT04453384.PMID:34181475 | DOI:10.1128/AAC.01237-21
Source: Antimicrobial Agents and Chemotherapy - June 28, 2021 Category: Microbiology Authors: Benjamin Gaborit Eric Dailly Bernard Vanhove R égis Josien Karine Lacombe Vincent Dubee Virginie Ferre Sophie Brouard Florence Ader Marie-Anne Vibet Aur élie Le Thuaut Richard Danger Laurent Flet Anne Omnes Laetitia Berly Anne Chiffoleau Alexandra Jober Source Type: research